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For ethical and financial reasons, there is a preference to minimize in vivo investigations to elucidate such behavior, but for subcutaneously administered drugs there is the added complication that correlations between animal models and human outcomes tend to be particularly poor

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doi:10.1016/j.ttbdis.2018.11.019 Kindler W, Wolf H, Thier K, Oberndorfer S

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(Photo: courtesy of Dennis Sparks) The powerful neurotoxin lead began leaching into the municipal water supply of Flint Michigan in April of 2014 when the city switched its water source and failed to add anti-corrosion agents